Thank you, {{form.email}}, for signing up. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Milk thistle is sometimes used to treat skin conditions including mild psoriasis. Talk to your doctor before taking any supplements because they might interfere with your medication. For example, in one study, researchers investigated the mood elevating effects of silymarin, a collection of phytochemicals extracted from milk thistle. Effects of Silybum marianum (L.) Gaertn. Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. Historically, people have used milk thistle for liver disorders and gallbladder problems. Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. CNS Neurosci Ther. Milk Thistle: Generic, Uses, Side Effects, Dosages - RxList Natural Medicines. But the herb is also believed to be beneficial for other health issues. This article will explore the uses of milk thistle and research on its potential benefits. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Dosing of milk thistle ranged from 150 mg twice a day to 300 mg twice a day. eCollection 2022. Theres some evidence that milk thistle can treat cirrhosis and chronic hepatitis, which can be caused by alcohol abuse, autoimmune disease, or viruses. Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. Pharmacol Rev. ", National Center of Complementary and Alternative Medicine (NCCAM): "Milk Thistle," Herbs at a Glance: Milk thistle., Medicinenet.com: "Generic Name: Milk Thistle Oral.". sharing sensitive information, make sure youre on a federal Milk thistle extract has a high amount of silymarin (between 6580%) that has been concentrated from the milk thistle plant. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Eighteen clinical trials of 1,088 participants were assessed. However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Eur Endocrinol. Other studies looking at milk thistle for cirrhosis have found conflicting results. You should not use this product if you are allergic to milk thistle or if you have: past or present cancer of the breast, uterus, or ovary; or. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. WebMD does not provide medical advice, diagnosis or treatment. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. Fluoxetine (Prozac), for instance, clocks in at roughly $16 for 21 capsules if youre buying with the drugs.com discount card, but the side effects are often not as easy to swallow (3). Dupuis ML, Conti F, Maselli A, et al. However, the evidence is conflicting. Milk thistle is a flowering herb native to Europe but is also found in parts of the United States, Australia, Asia, Africa, and South America. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. See additional information. Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. People with diabetes should use caution. Satisfaction. Here are 7 science-based benefits of milk thistle. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y, Seeff LB, Curto TM, Szabo G, et al. information is beneficial, we may combine your email and website usage information with And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. 2018;8:65-74. doi:10.2147/PTT.S169333. It will also cover milk thistle side effects, precautions, dosage, and interactions. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Milk Thistle Treatment for Children and Adults with - PubMed These include: Summary Milk thistle is generally considered safe. Psoriasis (Auckl). 2016;5147468. doi:10.1155/2016/5147468. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . Protective Effect of Silibinin on Learning and Memory Impairment in LPS-Treated Rats via ROS-BDNF-TrkB Pathway. *These statements have not been evaluated by the Food and Drug Administration. If you are a Mayo Clinic patient, this could Well go over the methods that doctors use to determine this and provide a chart, Blessed thistle is an herb with a long history of use for digestive issues and breastfeeding. Milk Thistle is used to treat alcoholic liver disease, gallbladder problems, hepatic cirrhosis, hepatitis (chronic), hepatotoxicity (chemical/drug-induced), jaundice, pleurisy, prostate cancer, and spleen diseases, and used as an appetite stimulant.. 10 Supplements You Should Be Taking After Menopause Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. Some medications have been known to interact with milk thistle negatively. Milk thistle and its antioxidant properties are promising in managing OCD symptoms but it may also be beneficial to explore other herbs for OCD treatment to bolster and round out a supplement regimen. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. I think milk thistle is often used in combo with NAC to enhance it's beneficial effects. Milk thistle is sold as an oral capsule, tablet and liquid extract. The https:// ensures that you are connecting to the Milk thistle is often sold as an herbal supplement. Recent research has explored the use of milk thistle. Silibinin significantly attenuated anxiety/depression-like behaviors caused by A1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). Minerals for OCD Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle is native to Europe and was introduced into North America by early colonists. This content does not have an Arabic version. FREE standard shipping only available in the contiguous United States. Anxiety; Autophagy; BDNF; Depression; Silibinin. N-Acetylcysteine Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. government site. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Milk thistle may interact with certain medications and supplements. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. The therapeutic potential of milk thistle in diabetes. Milk thistle may also be used for purposes not listed in this product guide. Summary Initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. Anticancer Drugs. 2. Not available for orders containing UltraNourish. By Brittany Lubeck, RD Find out more on the side effects of statins. Written by Cerner Multum. Liver Detoxification and Health. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. People sometimes eat the stem and leaves of milk thistle in salads. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver diseases. Milk Thistle (Silybum marianum) for Anxiety? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Together, you can make shared, well-informed decisions. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. 2014;2014:941085. doi:10.1155/2014/941085. Some, but not all, milk thistle supplements are vegan. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. National Library of Medicine 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful.

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